Product Name :
NUB1 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
BS4 antibody NEDD8 ultimate buster 1 antibody Negative regulator of ubiquitin like proteins 1 antibody Negative regulator of ubiquitin-like proteins 1 antibody NUB1 antibody NUB1_HUMAN antibody NUB1L antibody NY REN 18 antibody NYREN18 antibody Renal carcinoma antigen NY-REN-18 antibody
Function :
This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson’s disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splici
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
The antiserum was produced against synthesized peptide derived from human NYREN18.3-Hydroxycyclopentan-1-one Price AA range:566-615
Species reactivity:
Human, Mouse, Monkey
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Formula of 156939-62-7 Aliquot store at -20℃ or -80℃.PMID:33653188 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
70 kDa
Positive control :
Heart,Renal cell carcinoma,Retina,Testis,